News around the biocity campus

c-LEcta’s Enzyme enabled a novel enzyme cascade – the synthesis of biopolymer precursors

The economic synthesis of valuable compounds by multi enzymatic transformations is gaining more and more attention. This is because the combination of different enzyme activities can make novel, economic synthetic routes accessible and may drive reversible reaction to completion. At the same time the use of enzymes obviates the need for harmful reactants. Especially given by the possibility to create and to incorporate artificial (de novo or engineered wild type) enzymes into these processes, enzymes cascades become a promising powerful tool for the production of valuable compounds in various industries.

As a proof of concept, the group of Prof. Bernhard Hauer1 established a novel route from the natural feedstock ricinolelic acid to sebacic acid, which is used as a precursor for biopolymers. The reaction comprises a four enzymes cascade: two wild type, one de novo designed and one engineered enzyme from c-LEcta. Only due to the utilization of two artificial enzymes this reaction is rendered viable.

With respect to their future potential, enzyme cascades play an important role at c-LEcta and are used in a variety of product development projects of the company.

If you like to learn more about enzyme cascades in industrial biotechnology, please do not hesitate to contact us via

1Otte, K. B., Maurer, E., Kirtz, M., Grabs, D., Althoff, E., Bartsch, S., Vogel, A., Nestl, B. M. and Hauer, B. (2017), ChemCatChem. doi:10.1002/cctc.201601551

Previous News

BIO CITY LEIPZIG rated under the 15 Best Biotech Incubators in Europe

We proudly announce BIO CITY LEIPZIG beeing rated under the top 15 biotech incubators in Europe by

Next News

150,000 stem cell deposits at Vita 34

Vita 34 on the BioCity Campus Leipzig celebrates the 150000th stem cell storage and the 20th company anniversary with an international expert symposium on the application of stem cells in children. With 150,000 stem cell deposits from 29 countries in Europe and worldwide as well as 30 applications, Vita 34 is the largest and most experienced stem cell bank in the German-speaking countries.